Insulitis in Type 1 Diabetes: A Sticky Problem

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Insulitis in Type 1 Diabetes: A Sticky Problem

Lymphocytic infiltration in the islets of Langerhans is generally recognized as the defining lesion in young patients with recent-onset type 1A diabetes. In a landmark article published in Diabetes in 1965, Gepts (1) described insulitis in 70% of cases with acute diabetes and found that the lesion only affected islets with residual -cells in pancreatic organs that had otherwise lost most of the...

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Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

Type 1 diabetes (T1D) is an auto-immune disease characterized by the selective destruction of the insulin secreting beta cells in the pancreas during an inflammatory phase known as insulitis. Patients with T1D are typically dependent on the administration of externally provided insulin in order to manage blood glucose levels. Whilst technological developments have significantly improved both th...

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Perfluoralkylated substances (PFAS) are classified as persistent, bioaccumulative and toxic substances and are widespread environmental contaminants. Humans are exposed through food, drinking water and air. We have previously reported that bisphenol A accelerates spontaneous diabetes development in non-obese diabetic (NOD) mice and observed in the present study that perfluoroundecanoic acid, PF...

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ژورنال

عنوان ژورنال: Diabetes

سال: 2009

ISSN: 0012-1797,1939-327X

DOI: 10.2337/db09-0345